Araadenosine-5'-Triphosphate
Description
9-β-D-Arabinofuranosyladenine 5'-triphosphate (ara-ATP) is an active form of 9-β-D-arabinofuranosyladenine (Vidarabine) - a synthetic sugar-modified analog of natural adenosine - with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2) and varicella-zoster virus (VZV). When used with viral DNA polymerase, ara-ATP competes with dATP for incorporation into DNA leading to a termination of DNA synthesis. Ara-ATP is an inhibitor of human ribonucleotide reductase which is one of the key enzymes responsible for the synthesis of 2’-deoxyribonucleotides required for DNA synthesis. Ara-ATP also inhibits RNA polyadenylation which is essential for HIV-1 and other retroviruses. It is an inhibitor for S-adenosylhomocysteine hydrolase thus preventing trans-methylation reaction.
Product details
| Catalog No | N-1048 |
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 15 |
| Molecular Formula | C₁₀H₁₆N₅O₁₃P₃ (free acid) |
| Molecular Weight | 507.10 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H₂O |
| Recommended Storage | -20°C or below |
| Application | Aptamers |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Adenosine |
| Nucleotide Category | Sugar Modified |
| Shipping Temp | Frozen |
| Sugars | Ara |
Technical documents
- Safety Data Sheet Look-up open_in_new
Certificate of analysis
- Certificate of Analysis (CoA) open_in_new
Intellectual property
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