N6-Methyladenosine-5'-Triphosphate
Description
N6-methyl adenosine (N6-methyl ATP) is a base modified analog of adenosine and is found as a minor nucleoside in natural RNAs (Meyer et al.). N6-methyl ATP can substitute for ATP in some biological systems, and is a potent agonist for P2Y-purinoceptors in the guinea pig, taenia coli (Burnstock et al.). In vitro studies showed that N6-methyl ATP substituted for ATP and supported cytoskeletal filament-driven translocation of motor proteins (dynein, kinesin and myosin) (Schliwa et al. & Shimizu et al.). N6-methyl ATP is also a substrate for RNA polymerase and can be used for preparation of modified RNA (Rohayem & Kariko et al.).
Product details
| Catalog No | N-1013 |
| Purity | ≥90% by AX-HPLC |
| Extinction Coefficient | 15 |
| Molecular Formula | C₁₁H₁₈N₅O₁₃P₃ (free acid) |
| Molecular Weight | 521.20 g/mole (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H₂O |
| Recommended Storage | -20°C or below |
| Application | Aptamers |
| Backbone | 5'-Triphosphate |
| Base Analog(s) | Adenosine |
| Nucleotide Category | Base Modified RNA |
| Shipping Temp | Frozen |
| Sugars | RNA |
Technical documents
- Safety Data Sheet Look-up open_in_new
Certificate of analysis
- Certificate of Analysis (CoA) open_in_new
Intellectual property
Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.
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