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2'-Fluoro-2'-deoxycytidine-5'-Triphosphate

SKU: N-1008

Description

2'-Fluoro NTPs are being utilized in an increasing number of applications in research and new drug development. 2'-Fluoro-dCTP is incorporated in both DNA and RNA constructs to improve in vivo stability. Both 2' Fluoro dC and dU are used in the design and synthesis of aptamers, antagomirs and siRNA, because they impart increased target affinity and resistance to endonuclease degradation, while reducing immune response. A key technique utilized in aptamer development using 2'-Fluoro-dCTP is SELEX (Systematic Evolution of Ligands by Exponential Enrichment). The SELEX process allows for the simultaneous screening of 1 x 1015 different oligonucleotides against a target of interest, such as a protein. The main goal of SELEX is to identify a small subset of aptamers from the original library that bind to the target of interest. Learn more in the technical article: An Overview of the SELEX Process. "TriLink offers not just better pricing but specialized services at large scale and functional, quality 2’-Fluoro-dCTP and 2’-Fluoro-dUTP. TriLink's technical customer support was knowledgeable and gave me confidence about the products." Sriramchandra Mangipudi Bioengineer University of Washington, Seattle

Product details
Catalog No N-1008
Purity ≥95% by AX-HPLC
Extinction Coefficient 9
Molecular Formula C₉H₁₅N₃O₁₃P₃F (free acid)
Molecular Weight 485.10 g/mole (free acid)
Salt Form Li+
Concentration 100 mM
Buffer H₂O
Recommended Storage -20°C or below
Application Aptamers
Backbone 5'-Triphosphate
Base Analog(s) Cytidine
Nucleotide Category Sugar Modified
Shipping Temp Frozen
Sugars 2'-Fluoro

Technical documents

Certificate of analysis

Intellectual property

Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.

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