5-Hydroxymethyl-2'-deoxycytidine-5'-Triphosphate
Description
Methylated deoxycytidine analogs are well studied epigenetic modifications. 5-Hydroxymethyl-2'-deoxycytidine has recently been discovered in mammalian genomic DNA, but is substantially depleted in many types of human cancers. A strong inverse relationship has been demonstrated between the proliferation rate of cells and the global level of 5-hydroxymethyl-2'-deoxycytidine in both porcine and rat tissues, but no such relationship was observed for 5-formyl-2'-deoxycytidine and 5-carboxyl-2'-deoxycytidine.
Product details
| Catalog No | N-2060 |
| Purity | ≥90% by AX-HPLC |
| Molecular Formula | C₁₀H₁₈N₃O₁₄P₃ (free acid) |
| Salt Form | Li+ |
| Concentration | 100 mM |
| Buffer | H₂O |
| Application | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies |
| Base Analog(s) | Cytidine |
| Nucleotide Category | Base Modified DNA |
| Shipping Temp | Frozen |
| Extinction Coefficient | 7,700 Lmol |
| Molecular Weight | 497.2 |
| Recommended Storage | -20°C ± 5°C |
| Sugar Classification | dNTP |
| Modifications | 5-Hydroxymethyl |
| Synonyms | 5-HMe-dCTP |
Technical documents
- Safety Data Sheet Look-up open_in_new
Certificate of analysis
- Certificate of Analysis (CoA) open_in_new
Intellectual property
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