SpCas9

SpCas9 is an RNA-guided DNA endonuclease from the CRISPR-Cas immune system of Streptococcus pyogenes. Guided by a single-guide RNA (sgRNA), it recognizes target DNA sequences adjacent to a 5'-NGG-3' PAM and introduces a site-specific double-strand break through its HNH and RuvC nuclease domains. As a programmable DNA-editing biomodule, SpCas9 enables precise genome modification, gene regulation, and synthetic biology applications.

  • Part ID GLBHEEW
  • Name SpCas9
  • Alternative Name -
  • Version -
  • Division -
  • Parent Sequence -
  • Collection -
  • Part Status Valid
  • Public check_circle
  • Experimentally validated check_circle
  • Length 80
  • Source Strain -
  • Suitable for
  • Registry Code -
  • Contains
  • Created by TriLink Biotech
  • Created at June 10, 2026, 2:36 p.m.
  • Last Edit June 10, 2026, 3:03 p.m.